Ducati won the top category with Australian Casey Stoner in 2007, ending a 32-year Japanese manufacturer domination of the sport.
The Bologna-based company also secured the MotoGP constructors' title last season following a 50 point deduction for Yamaha. Suzuki took the rider and team titles with Spaniard Joan Mir.
The factory Ducati team has a new lineup for 2021 with Australian Jack Miller and Italian Francesco Bagnaia.
"Racing has always been a truly fundamental part of the Ducati brand and will remain so in the future," said Ducati CEO Claudio Domenicali in a statement.
"This renewed agreement confirms that, while we plan to continue to expand our product range outside of the world of sports bikes, the track and high-performance motorbikes remain a central element for Ducati."
